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KMID : 0370219960400030357
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Yakhak Hoeji
1996 Volume.40 No. 3 p.357 ~ p.368
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Evaluation of in vitro Antibacterial Activity of DWP20373, a Novel Fluoroquinolone
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김지연/Kim JY
최문정/한승희/김병오/심점순/정연의/이재욱/유영효/박명환/Choi MJ/Han SH/Kim BO/Shim JS/Jung YE/Lee JW/Yu YH/Park MH
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Abstract
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The in vitro antibacterial activity of a novel fluoroquinolone, DWP20373(1-Cyclopropyl-6-fluoro-8-methoxy-7-(2,7-diazabicyclo[3,3,0]oct-4-ene-7-yl)-1,4-dihydro-4 oxoquinoline-3carboxylic acid) was compared with those of ciprofloxacin (CPFX), sparfloxacin (SPFX) and ofloxacin (OFLX). DWP20373 was more active than SPFX and OFLX but was less potent than CPFX against gram-negative bacteria. DWP20373 showed an excellent activity against L-MRSA and H-MRSA (MlC90=0.781~1.563mcg/ml).The activity of DWP20373 decreased moderately in the presence of 5mM Mg2+. However, pH and serum had no effect on the activity of DWP20373. DWP20373 possessed a rapid bactericidal activity against gram-positive and gram-negative strains.
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